Inhibitory and complementary therapeutic effect of sweet lime (Citrus limetta) against RNA-viruses

Original Article

Author Details : Swapan Banerjee, Sulagna Ray Pal*

Volume : 7, Issue : 1, Year : 2021

Article Page : 37-44

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Sweet lime (Citrus limetta), known as 'Mousambi' or 'Mosambi' in India, is one of the best citrus fruits regarding its nutrient contents. Its bioactive compounds (BAC) are exclusively used for multiple clinical applications considering many therapeutic benefits not only in Asian countries but also in the western world. The fruit pulp and juice are the best sources of ascorbic acid, B-vitamins, amino acids, and other secondary metabolites. Specifically, polyphenols such as flavanones, hesperetin, naringenin, and chlorogenic acid are highly rich in the fruit. The nutrients in sweet lime altogether provide significant anti-inflammatory, antioxidant, anti-cancer, and neuroprotective effects. The purpose of this study is to review and analyze the inhibitory and complementary therapeutic effects of sweet lime's pulp and juices to inhibit the virulence caused by RNA viruses, mainly SARS-CoV-2. This review study was designed based on extensive online searches of relevant open-access literature available in the best quality and reliable databases by using specific keywords and boolean operators. After a rigorous review, we found that flavanones in the fruit can alter or inhibit the polyproteins (pp1a and pp1b) responsible for viral replication. Therefore, sweet lime has potentialities to provide an inhibitory and a complementary therapeutic effect against RNA viruses, mainly SARS-CoV-2. About the antiviral activities, more clinical trials are needed to prove its efficacy; however, reviewing current knowledge, is one of the potent antioxidant, inflammatory fruits available and affordable almost worldwide.

Keywords: Mosambi, Sweet lime's benefits, Polyphenols, COVID­19 nutrition, Sweet lime's therapeutic effect, Immunity

How to cite : Banerjee S, Pal S R, Inhibitory and complementary therapeutic effect of sweet lime (Citrus limetta) against RNA-viruses. J Prev Med Holist Health 2021;7(1):37-44

Copyright © 2021 by author(s) and J Prev Med Holist Health. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (

Article History

Received : 31-05-2021

Accepted : 10-06-2021

Available online : 13-07-2021

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